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到,停药后5年内复发率仍超过50%,而长期用药更伴随肾损伤与骨代谢风险。  在TDF的基础上,吉利德于2016年推出了富马酸丙酚替诺福韦(TAF),通过前药设计精准递送活性成分至肝脏,在保持疗效同时将肾毒性风险压降90%,骨安全性显著提升。然而,即使被外界称为“乙肝神药”,TAF的HBsAg清除率仍徘徊于3%以下,“抑制而非治愈”的局限仍未突破。  面对困境,当前乙肝治疗的理想目标是功能性治愈,即

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